The ATLAS and CMS collaborations have measured the Higgs boson in various production and decay modes. These measurements still leave room for exotic Higgs boson couplings proposed by straightforward extensions of the Standard Model (SM). In this talk, the results based on a search performed in the context of a two-Higgs doublet model extended with a scalar (2HDM+S), using 138 fb-1 p-p collision data collected by the CMS experiment in the Run-2 of LHC in the 2τ2b final state, will be presented.